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Vol. 1 No. 3: Fall Equinox, 1999
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Cardiovascular Disease and Diabetes
continued...
Summary
The final answer will come from further research. We have started a study attempting to improve outcomes in patients with diabetes undergoing cardiac bypass surgery. Diabetic patients have approximately double the complication rate compared to people without diabetes having the same surgery. We are going to test the hypothesis that controlling all the metabolic risk factors discussed above - glucose, cholesterol, blood pressure and protecting the arterial wall - will significantly reduce complications. Not only could this benefit the patient but it may also reduce the average length of hospital stay and reduce the costs to the health care system. This project and others will, we hope, shed light on the relationship between blood sugar control and macrovascular disease. Regardless of the findings, however, it is still very important to control glucose levels in people with diabetes because of the dramatic benefit that this has on reducing the risk of microvascular complications.
Dr. David Thompson is the acting head of the Division of Endocrinology at University of British Columbia. He is an expert in diabetes and maintains a medical practice as well as a research program.
References
- The Diabetes Care and Complications Trial Research Group. Effect of intensive diabetes management on macrovascular events and risk factors in the The Diabetes Care and Complications Trial. Am. J. Cardiol. 1995; 75: 984-903.
- UKPDS (United Kingdom Prospective Diabetes Study);. Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-865.
- UKPDS (United Kingdom Prospective Diabetes Study). Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-853.
- Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diab Res Clin Pract 1995;28:103-117.
- Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P, Waldenstrom A, Wedel H, Welin I. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year. J Am Coll Cardiol 1995;26:57-65.
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Vol. 1 No. 3: Fall Equinox, 1999
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